By Richard T. Johnson
As with prior versions, this is often certain to develop into the best-selling inner medication 'Current treatment' e-book. all through, well known pros current their very own reports within the administration of particular issues affecting the fearful process. prognosis, epidemiology, and pathophysiology are mentioned in simple terms once they impact remedy techniques and judgements.
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Extra info for Current Therapy in Neurologic Disease
May be used at very high doses, to seizure remission • Mixing barbiturates and benzodiazepines should be done with caution in unintubated infants, because of potential respiratory depression. Seizures persist FIGURE 1. Algorithm for management of neonatal seizures. CBC, Complete blood count; CSF, cerebrospinal fluid; EEG, electroencephalogram; PB, phenobarbital. ALGORITHM FOR MANAGEMENT OF INFANTILE SPASMS 1. Establish the diagnosis • History/physical: to rule out (sleep) myoclonus, myoclonic seizures, GE reflux The age, clusters of spasms, hypsarrhythmic EEG are diagnostic • Consider treatable causes (mass lesion, metabolic derangement).
Lammers GJ, Overeem S: Pharmacological management of narcolepsy, Expert Opin Pharmacother 4:1739-1746, 2003. Mignot E, Lammers GJ, Ripley B, et al: The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias, Arch Neurol 59:1553-1562, 2002. Mignot E, Lin L, Rogers W, et al: Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups, Am J Hum Genet 68:686-699, 2001. Taheri S, Zeitzer JM, Mignot E: The role of hypocretins (orexins) in sleep regulation and narcolepsy, Annu Rev Neurosci 25:283-313, 2002.
A seizure in the setting of a fever must be excluded from a seizure resulting from meningitis. Generally this is not difficult since an alternative source can be found or the child is acting normally without evidence of significant illness. A lumbar puncture (LP) should be done whenever there is concern about the possibility of meningitis. It is usually performed in children younger than 1 year of age who have had a first febrile seizure and in settings where there is concern about the reliability of remaining in contact with the medical care providers.
Current Therapy in Neurologic Disease by Richard T. Johnson