By Mohammad Fahad Ullah, Aamir Ahmad
This e-book makes a speciality of the prophylactic capability of diet-derived elements in basic prevention of melanoma. it truly is written by way of a bunch of hugely reputed specialists within the quarter of nutritional brokers and melanoma chemoprevention. The translational capability of nutritional components from epidemiological, laboratory and scientific experiences as prevention method in general and chance populations is highlighted. The work presents options of routine inclusion of particular nutritional regimens for prevention in addition to healing procedure for greater administration via adjuvant interventions in melanoma remedy.
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Extra resources for Critical dietary factors in cancer chemoprevention
Nature (London) 360:355–358 Aviram M, Dornfeld L (2001) Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 158:195–198 Badawi AF (2000) The role of prostaglandin synthesis in prostate cancer. M. Adhami and H. Mukhtar Beebe-Dimmer JL, Wood DP Jr, Gruber SB, Douglas JA, Bonner JD, Mohai C, Zuhlke KA, Shepherd C, Cooney KA (2004) Use of complementary and alternative medicine in men with family history of prostate cancer: a pilot study.
Yu et al. (Yu et al. 2004) demonstrated that the addition of EGCG and Cu2+ to the growth medium decreased the relative viability of human PCa cells. In a study from our laboratory, EGCG was also found to increase the expression of cell cycle regulatory molecules p21, p16, and p18 while downmodulating the protein levels of cyclin D1, cyclin E, cdk2, cdk4, and cdk6 (Gupta et al. 2003). We then reasoned that the preclinical studies should be carried out in a model system that mimics the PCa development in a similar fashion to human disease.
Biochem Biophys Res Commun 204:898–904 Jain A, Martin MC, Parveen N, Khan NU, Parish JH, Hadi SM (1999) Reactivities of flavonoids with different hydroxyl substituents for the cleavage of DNA in the presence of Cu(II). Phytother Res 13:1–4 Khan HY, Zubair H, Faisal M, Ullah MF, Farhan M, Sarkar FH, Ahmad A, Hadi SM (2014) Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: a mechanism for cancer chemopreventive action.
Critical dietary factors in cancer chemoprevention by Mohammad Fahad Ullah, Aamir Ahmad