Congenital Diseases and the Environment - download pdf or read online

By A. Mantovani, F. Maranghi (auth.), P. Nicolopoulou-Stamati, L. Hens, C.V. Howard (eds.)

ISBN-10: 1402048300

ISBN-13: 9781402048302

ISBN-10: 1402048319

ISBN-13: 9781402048319

In fresh years, expanding realization and assets were dropped at undergo at the dating among the surroundings and congenital illnesses. those illnesses have been formerly regarded as regularly because of genetic explanations. although the significance of genes as components in causation is approved, environmental components appear to be implicated simply as strongly. This ebook explores a few extra suggestions that experience arisen from newer perceptions of environmental results and their attainable interactions with residing platforms. dialogue and presentation of previous and novel rules is concentrated at constructing a extra holistic and united conception of the interplay among congenital illnesses and the environment.

Amongst the themes mentioned are:

-effects of prenatal publicity to poisonous chemicals

-intra-uterine publicity to medicines

-effects of endocrine disrupters

-environmental probability and intercourse ratio in newborns

-surveillance of environmental impact

-research and policy

This booklet may be of curiosity to researchers in environmental technological know-how and/or human ecology, future health pros, NGOs, and the overall public.

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Additional resources for Congenital Diseases and the Environment

Sample text

341 Table 26. 342 Table 27. 344 Table 28. 345 Table 29. 346 Table 30. 347 Table 31. Infant mortality rates in Bulgaria due to congenital anomalies and certain conditions, originating during prenatal period 2003.................. 348 Table 32. 348 Table 33. 349 Table 34. 351 Table 35. 352 LIST OF TABLES xxxv Table 36. 353 Table 37. 363 Table 38. 365 Table 39. 371 Table 40. 386 Table 41. 387 Table 42. Endocrine disrupter research projects: Assays being developed, animals (incl. 389 Table 43. 397 Table 44.

MARANGHI 22 induce long-term effects upon exposure in susceptible developmental phases, including postnatal life up to puberty; b) the potential impact of endocrine disruption on immune, neurobehavioral and reproductive development as well as on susceptibility to cancer later in life. Therefore, tiered approaches have to be developed. mechanisms/endpoints to be investigated by targeted two-generation assays; these would allow the follow-up of late outcomes and the identification of relevant NOELs for the most sensitive effects.

Pollut. Res. Int. 11, 347-348. SECTION 1: METHODS ENDPOINTS FOR PRENATAL EXPOSURES IN TOXICOLOGICAL STUDIES A. MANTOVANI* AND F. it) Summary The standard approach to developmental toxicology includes, 1) studies targeting the organogenesis/pregnancy period, to assess birth defects, minor anomalies (that may be a signal of more severe effects at higher dose levels), fetal growth and viability (OECD guideline 414); 2) one- and two-generation studies (OECD guidelines 415 and 416) that provide an overall assessment of general parameters related to postnatal development and survival.

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Congenital Diseases and the Environment by A. Mantovani, F. Maranghi (auth.), P. Nicolopoulou-Stamati, L. Hens, C.V. Howard (eds.)


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