New PDF release: Clinical Oncology Fourth Edition: Basic Principles and

By Neal, Anthony J

ISBN-10: 0340972939

ISBN-13: 9780340972939

ISBN-10: 1444166441

ISBN-13: 9781444166446

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Extra info for Clinical Oncology Fourth Edition: Basic Principles and Practice

Example text

Breast cancer is a common cancer and therefore even a very small treatment effect of, say, an improvement in survival of 5 per cent over 10 years will result in many thousands of women worldwide living for longer after breast cancer. However, for the individual woman the odds that she will benefit from adjuvant treatment in that setting are small and it is possible that she will undergo a toxic treatment with no effect on her ultimate survival. It is also difficult for those around the patient, be they family, friends or physicians, to evaluate and balance the risks of having a toxic treatment against the risk of relapse, particularly when there can never be the certainty of cure.

A negative result makes cancer very unlikely g. Very useful for immediate diagnosis of lymphoma 2. Which of the following is the least important objective of staging cancer? a. Provides baseline of current disease status for assessing response to treatment b. Allows optimization of treatment c. Informs both patient and clinician d. Allows time for patient to come to terms with diagnosis e. Gives insight into likely prognosis 3. Which three of the following statements apply to an isotope bone scan?

For example if a standard treatment has a known response rate of 70 per cent and 5-year survival of 45 per cent, the trial investigators must decide what improvement upon this they would expect, or wish to detect, in their trial. e. how Clinical evidence and clinical trials certain they wish to be of their result at the end. As an example, if a particular treatment has a survival rate of 50 per cent, in order to reliably detect an absolute improvement of 10– 60 per cent from a new treatment, approximately 400 patients will be required to enter a randomized trial comparing the two.

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Clinical Oncology Fourth Edition: Basic Principles and Practice by Neal, Anthony J


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