By L. A. Cannizzaro
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Additional info for Cancer Genomics
A total of four genes were present in at least three signatures. Three of these (HLA-DPB1, ARHGDIB and C14orf139) were present in two model signatures and one tissue signature, whereas the CTGF gene was present in three model signatures but no tissue signature. Chromosomal location and alignment with CGH studies Alignment of the genes in the signature intersect list with chromosomal location reveals that they are randomly spread across the genome with extremes being an absence of any genes on chromosome 5, and seven genes being located on chromosome 6.
1996). , 1999). , 2006). Breast cancer is clearly a heterogeneous disease and microarray analysis has been successfully used to derive distinct patterns of gene expression that correlate with molecular subtypes of breast cancers. , 2005). These breast cancer subtypes also represent clinically distinct subgroups of patients, with differences in disease progression and overall survival. For example, ER-positive tumors tend to have the best outcome, whereas HER2+ tumors have a bad prognosis. , 2006).
2005). Immunohistochemical confirmation in human breast tissue specimens of the expression of three markers, heat shock protein 70 (HSP70), chemokine ligand 1 (CXCL1), and secretory leukocyte protease inhibitor (SLPI), revealed that the expression of all three genes was correlated with lymph node involvement, and the expression of HSP70 and CXCL1 was associated with decreased overall patient survival. , 2004). A wholly murine model of spontaneous breast cancer metastasis to multiple sites has been characterized and used to identify genes involved in metastatic progression.
Cancer Genomics by L. A. Cannizzaro