By Val Speechley, Maxine Rosenfield, Richenda Milton-Thompson, David Woodroffe, Jane Taylor
Melanoma at Your Fingertips is a useful reference advisor, which supplies transparent, authoritative and functional information regarding melanoma. Written by way of specialists within the box, this handbook solutions over 450 genuine questions that folks most ordinarily ask.
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Knowledge gained from these studies might ultimately produce means of exploiting the control of EBV gene expression to augment immune destruction of EBV-infected malignant cells in such catastrophic diseases as Burkitt lymphoma or Hodgkin's disease. ; Harvard University (Medical School) Medical School Campus Boston, Ma 02115 Timing: Fiscal Year 2001 Summary: The epidemiology of Hodgkin's disease (HD) is consistent with a viral etiology. The Epstein-Barr virus (EBV) is closely related to HD on the basis of both serologic and molecular evidence, with 30- 50% of the cases' biopsies being EBV-genome positive.
Mutational spectra of hprt and p53 mutations will be determined by a variety of methods including multiplex PCR, RT-PCR, IPCR, Southern blotting and DNA sequencing. Clonality of hypermutable clones will be determined by RFLP analysis of TCR gamma and CDR3 region DNA sequence analysis of TCR-beta. These studies will provide the first data on the frequency and mutational spectrum of in vivo spontaneous or treatment induced somatic mutations in children with specific malignancies. The investigators will also begin to determine the potential mutagenic effects associated [with] background "illegitimate" V(D)J recombinase mediated events in a known cancer gene, p53.
Are they bona fide memory cells? Does antigen play a role in the production and/or maintenance of these memory cells or do latent proteins perform these functions? How rapidly do the infected cells turn over? 4. g. tonsils infected with EBV in vivo or infectable in vitro? Previous studies have analyzed EBV infection of epithelial cell lines and tissues from sites other than the site of persistent infection - the nasopharyngeal lymphoid tissue. However, epithelial tissues are biologically diverse so we will focus our studies on the biologically relevant epithelium from the tonsil.
Cancer at Your Fingertips by Val Speechley, Maxine Rosenfield, Richenda Milton-Thompson, David Woodroffe, Jane Taylor