By Edward B Stelow MD, Stacey Mills
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Extra info for Biopsy Interpretation of the Upper Aerodigestive Tract and Ear
1977;5:69-75. 13. Crissman JD. Laryngeal keratosis and subsequent carcinoma. Head Neck Surg. 1979;1:386-391. 14. Henry RC. The transformation of laryngeal leucoplakia to cancer. J Laryngol Otol. 1979;93:447-459. 15. Crissman JD, Zarbo RJ. Dysplasia, in situ carcinoma, and progression to invasive squamous cell carcinoma of the upper aerodigestive tract. Am J Surg Pathol. 1989;13(suppl 1):5-16. 16. Lumerman H, Freedman P, Kerpel S. Oral epithelial dysplasia and the development of invasive squamous cell carcinoma.
An interesting precancerous condition occurs in patients who chew areca nuts either alone or in a mixture that sometimes contains tobacco (betel quid). The chewing can lead to a progressive histologic abnormality known as oral submucous fibrosis, which is characterized by the deposition of fibrous, collagen bands immediately beneath the squamous epithelium (Fig. 8). The epithelium also appears atrophic and dysplasia may be present. ANCILLARY STUDIES Ancillary studies are usually not very helpful for diagnosing precursor lesions, likely due to the heterogeneous molecular events that can lead to squamous cell carcinoma of the upper aerodigestive tract.
13). Conversely, some poorly differentiated tumors can display a sheetlike pattern of growth. The cells exhibit little maturation and thus may appear more monomorphic, with centrally located cells showing little cytologic difference from those toward the periphery of the infiltrating nests. 7 Single-cell infiltration is seen with this poorly differentiated squamous cell carcinoma. 52 –––––– biopsy interpretation of the upper aerodigestive tract and ear may show marked nuclear pleomorphism. Most cells have coarsely granular and obviously malignant chromatin.
Biopsy Interpretation of the Upper Aerodigestive Tract and Ear by Edward B Stelow MD, Stacey Mills