By E. Edward Bittar (Eds.)
With the present emphasis in melanoma learn on oncogenes and suppressor genes, and on autocrine elements and their receptors, possible finish that the ''whole story''can be learn within the melanoma mobile per se. nobody could deny that the large fresh advances in describing the molecular and mobile adjustments in melanoma cells have significantly extra to our knowing of neoplasia. yet, studying the way to translate the that means of those changes into methods of treating and, larger but, fighting melanoma would require not less than as deep an figuring out of the context during which it develops. the subjects of this quantity have been chosen to steer the reader throughout the advanced sequence of occasions during which melanoma cells and their ''environment''interact to supply malignant disorder. Underlying issues are the variety within the pathways which could result in malignancy and the elemental heterogeneity of neoplastic phone populations. As has frequently been stated, in melanoma no generalizations are consistently actual (including this one). hence, some of the chapters needs to be seen as examples of attainable strategies and mechanisms, no longer as universally appropriate legislation.
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1984; Mulder and Brattain, 1989a). , 1984; Herlyn, 1992). As our concepts of tumor heterogeneity solidified in the 1970’s it became apparent that an individual cell line, whether it be of animal or human origin, could not provide an adequate model for the biological, biochemical or pharmacological properties of a given histopathological type of tumor. These banks of cell lines were established in an attempt to obtain a broad spectrum of properties through a large number of cell lines which would be reflective of the diversity encountered in vivo.
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Biology of the Cancer Cell by E. Edward Bittar (Eds.)