Atrial Hormones and Other Natriuretic Factors - download pdf or read online

By Adolfo J. De Bold (auth.), Patrick J. Mulrow, Robert Schrier (eds.)

ISBN-10: 0683061542

ISBN-13: 9780683061543

ISBN-10: 1461475295

ISBN-13: 9781461475293

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Extra info for Atrial Hormones and Other Natriuretic Factors

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9) with the structure Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly1 Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr A low-molecular-weight peptide was also recognized in human plasma as the circulating form (29, 64). These findings indicated that ANF is synthesized as preproANF with 152 amino acid residues, processed to proANF with 126 amino acid residues, and stored in this prohormone form. However, when it is secreted it is converted to the low-molecular-weight form with 28-amino acid residue peptide.

35. SHAMOO, A. , AND I. S. AMBUDKAR. Regulation of calcium transport in cardiac cells. Can. J. Physiol. Pharmacal. 62: 9-22, 1984. 36. , R. S. SIDER, E. A. 0STAFIN, AND R. J. GREKIN. Plasma levels of immunoreactive atrial natriuretic factor in healthy subjects and in patients with edema. J. Clin. Invest. 76: 1684-1687, 1985. 37. , R. F. KREBS, AND A. T. VERESS. Release of atrial natriuretic factor from incubated rat heart atria. IRCS Med. Sci. Libr. Compend. 12: 783-784, 1984. 38. , AND A. T. VERESS.

Consistent with this, membrane-bound electron-dense granules appear in the atria and ventricles of embryonic humans, mice, and rats (4, 11). These granules then disappear in later embryonic life from the ventricle but remain in the atrium. Atriopeptin has been demonstrated to have mitogenic activity on one cell type, adrenal zona glomerulosa (8), and given the timing of AP appearance in the ventricle, AP may have a role in the normal growth and development of the heart. REFERENCES 1. , J. GUTKOWSKA, G.

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Atrial Hormones and Other Natriuretic Factors by Adolfo J. De Bold (auth.), Patrick J. Mulrow, Robert Schrier (eds.)


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