Application of Apoptosis to Cancer Treatment - download pdf or read online

By Mels Sluyser

ISBN-10: 1402033028

ISBN-13: 9781402033025

ISBN-10: 1402033036

ISBN-13: 9781402033032

Novel medicines are being constructed which engage with the programmed telephone demise (apoptotic) equipment in melanoma cells, thereby inflicting those cells to dedicate suicide and to be faraway from the physique. examine can be directed to enquire why the melanoma cells occasionally lose the facility to endure apoptosis after a undeniable time period and techniques are being built to reactivate this phone loss of life procedure. This booklet is meant for employees within the box and clinicians as an invaluable advisor of the scenario during this interesting box that could supply greater percentages for therapy of melanoma sufferers. Mels Sluyser is the Editor of the journals APOPTOSIS and ANTI-CANCER medicines. He brings jointly a suite of papers written through the world’s best specialists in those fields.

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USA 94:12999-13004. 34. , 1998, Calreticulin: an intracellular Ca2+-binding protein abundantly expressed and regulated by androgen in prostatic epithelial cells, Endocrinology 139:4337-4344. 35. , 2001, The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramideinduced apoptosis: significance for the molecular mechanism of Bcl-2 action, EMBO J. 20:2690-2701. 36. , 1994, The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgenindependent prostatic cancer cells induced by thapsigargin, Cancer Res.

NF-kappaB in cancer: a marked target. Semin Cancer Bioll 2003; 13: 107-114. 170. Cao Y, Karin M. NF-kappaB in mammary gland development and breast cancer. J Mammary Gland Biol Neoplasia 2003; 8: 215-223. 171. Eid MA, Lewis RW, Abdel-Mageed AB, Kumar MV. Reduced response of prostate cancer cells to TRAIL is modulated by NFkappaB-mediated inhibition of caspases and Bid activation. Int J Oncoll 2002; 21: 111-117. 172. Meli M et al. NF-kappaB inhibition restores sensitivity to Fas-mediated apoptosis in lymphoma cell lines.

6:1028-1042. 3. , 1998, Calcium - a life and death signal, Nature 395:645-648. 4. , 2001, Global cancer statistics in the year 2000, Lancet Oncol. 2:533-543. 5. , 2003, Regulation of cell death: the calcium-apoptosis link, Nat. Rev. Mol. Cell Biol. 4:552-565. 6. , 2001, The development of androgen-independent prostate cancer, Nat. Rev. Cancer. 1:34-45. 7. , 1996, Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer, Prostate 28:251-265. 8. , 1995, Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo, Cancer Res.

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Application of Apoptosis to Cancer Treatment by Mels Sluyser

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