Antitumour and Antiviral Substances of Natural Origin - download pdf or read online

By Edward S. Meek M D, Ch B, MRC Path (auth.)

ISBN-10: 3642462367

ISBN-13: 9783642462368

ISBN-10: 3642462383

ISBN-13: 9783642462382

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Ange affects the steric requirements of the second site, and also the biological properties of the protein. TOMKINS and MAXWELL (1963) have discussed this as a possible means of control of protein synthesis or membrane permeability. anism of action in detail. Tissue Extracts From time to time reports have appeared of antitumour substances present in various body tissues. The work of BULLOUGH and LAWRENCE, first reported in 1960, showed that in normal mammalian skin a substance is present which.

On testing for effects against 25 primary growths of human tumours in vitro, considerable antitumour activity was demonstrated in a number of cases; these preparations were particularly effective against sarcomas. STEPHENS (1964) found that albumen and associated material from eggs reduced the growth of certain experimental tumours, and apparently affected the extent of their differentiation. OTSUKA and TERAYAMA (1966) reported that normal liver contains a substance which inhibits the synthesis of DNA in hepatoma cells, whilst FREED and SOROF (1966) also found inhibition of cell multiplication resulting from the action of a certain type of liver protein.

In vitro, both active and inactive vaccinia virus preparations destroyed the leukaemia cells. More recently, MCGEE (1966) injected smallpox vaccine into 65 patients bearing 165 warts. After some local reaction, 164 of these warts vanished without trace, the process being accompanied by lymphocytic infiltration confined to the dermis. Heatattenuated and UV-inactivated smallpox vaccine was also tried, but no reaction or regression was obtained with either of these preparations. The author points out that interferon production may be concerned in the reaction.

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Antitumour and Antiviral Substances of Natural Origin by Edward S. Meek M D, Ch B, MRC Path (auth.)


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