By Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)
Basic learn on osteoarthritis has been conducted frequently from the his tological and biochemical points of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical tension has been proven to be the relevant consider the initiation of osteoarthritis. even supposing the precise strategy wherein mechanical pressure ends up in the complete destruction of cartilage tissue is still doubtful, numerous new learn equipment have enabled us to achieve a deeper realizing of the method of degeneration. In October 1997, we equipped a world symposium titled "Ad vances in Osteoarthritis" in Kobe, with the most subject matters being up to date re seek, prognosis, and therapy of osteoarthritis. The court cases of the symposium are awarded the following in 5 sections: (1) Mechanical rigidity and reactions of chondrocytes, akin to intracellular ion alterations, alterations within the cytoskeleton, intracellular messenger platforms, unencumber of fuel mediators, and adjustments in electromechanical houses of cartilage; (2) practical analysis of osteoarthritis by means of MR imaging, and utilizing calpain and collagenase III as new cartilage markers; (3) remedy with a promising easy washout approach and IL-1RA and MMP antagonists; (4) Cartilage fix through new grafting tech niques; and (5) difficulties following overall joint substitute. We basically desire that the complicated wisdom supplied during this quantity of court cases might be useful to our readers.
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Extra resources for Advances in Osteoarthritis
40 K. Fukuda et al. Lower mess level I Higher SIres level • 6 8 6 I -,-- 4 4 2 O trelch Control L-~ ____- L__ Control ~ ______L - lretch FIG. 2. Effect of cyclic tensile stretch on proteoglycan synthesis in bovine articular chondrocytes. Cells were seeded at a density of 2 X 105 cells/ml in specially built, flexible-bottom culture plates. The stretch regimens are given in Table 1. Proteoglycan synthesis was measured based on [35 S]sulfate incorporation. Data are expressed as the mean ::':: SD of 6 wells.
Hydrostatic pressurization thus offers an interesting experimental model with which to study the regulation of chondrocyte matrix production by a naturally occurring environmental factor. At present, we do not know by which mechanism the change of hydrostatic pressure is sensed by the chondrocytes and how the pressure affects the transcription, translation, and glycosylation of the PGs. New, unknown genes might be involved, stressing the importance of the current methods used in molecular biology to aid us in our search for specific genes affected by the pressure.
Changes in the Golgi Apparatus and Cytoskeleton of Chondrocytes Under High Hydrostatic Pressure After 30-MPa continuous hydrostatic pressure for 2h, the morphology of the chondrocytes was altered to a more retracted form. The stress fibers disappeared from the center of the cells, and only small punctually distributed material was stained (Fig. 5B). When 30-MPa pressure was applied cyclically, the number of the stress fibers was reduced and the remaining fibers were thinner than in control cells.
Advances in Osteoarthritis by Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)