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By Shamlal Mangray, Ronald A. DeLellis (auth.), Michael A. Blake, Giles Boland (eds.)

ISBN-10: 1597455601

ISBN-13: 9781597455602

ISBN-10: 193411586X

ISBN-13: 9781934115862

Imaging of the adrenal gland has made great growth within the final decade as new applied sciences proceed to conform. Adrenal Imaging highlights the pertinent medical and pathological info that underpins the actual interpretation and use of adrenal imaging. Written via a prestigious team of foreign individuals, person chapters in Adrenal Imaging function a suitable and up to date reference of adrenal imaging findings, algorithms and methods in CT, MR nuclear drugs, intervention, and trauma. precis sections on the finish of every bankruptcy remove darkness from key instructing issues to reinforce retention.

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The nuclei of pheochromocytoma cells are round to ovoid, with coarsely clumped chromatin and a single prominent nucleolus. Nuclear pleomorphism and hyperchromasia may be particularly prominent in some pheochromocytomas, but this finding does not correlate with malignant behavior. Benign pheochromocytomas can occasionally contain mitotic figures. Large tumors frequently display areas of hemorrhage and necrosis. The stroma may have areas of myxoid change with foci of lymphocytic infiltration. Amyloid deposits have been identified in up to 70% of pheochromocytomas in some series, while other series have reported the presence of amyloid in a significantly smaller proportion of cases [65].

Interestingly, normal and neoplastic chromaffin cells are capable of differentiation into ganglion cells under the influence of nerve growth factor [70]. It has been suggested that the sustentacular cells of pheochromocytomas could serve as the progenitors of the malignant peripheral nerve 22 Fig. 13 This microscopic section of a pheochromcytoma highlights the ‘‘Zellballen’’ pattern (A). A stain for S-100 protein highlights the sustentacular cells (B) Fig. 14 Microscopic section of a composite tumor composed of pheochromocytoma (PHEO) and ganglioneuroma (GN).

44 ................................. 36 Radiological Evaluation of Cushing’s Syndrome ......... 45 ....................................................... 37 Differential Diagnosis ................................................ Pseudo-Cushing’s Syndrome ..................................... 45 45 Steroid Metabolism and Excretion ............................. Glucocorticoids ......................................................... Mineralocorticoids ....................................................

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Adrenal Imaging by Shamlal Mangray, Ronald A. DeLellis (auth.), Michael A. Blake, Giles Boland (eds.)


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