ACE Inhibitors - download pdf or read online

By John R. Vane (auth.), Pedro D’Orléans-Juste, Gérard E. Plante (eds.)

ISBN-10: 3034875797

ISBN-13: 9783034875790

ISBN-10: 3034875819

ISBN-13: 9783034875813

Angiotensin changing enzyme inhibitors (ACEI) signify the 1st category of antihypertensive brokers that used to be designed and constructed at the foundation of a well-defined physiopathological axis of arterial high blood pressure, a vascular dis­ order that's now turning into one of many significant factors of morbidity/mortality, not just in constructed societies but in addition within the hugely populated constructing coun­ attempts [1]. CAPTOPRIL, the prototype of the "PRIL" kin, which now includes greater than forty molecule-species, was once relatively dangerous and the scientific increase­ ment nearly failed whilst critical side-effects have been stated in an alarmist fash­ ion in respected clinical journals, akin to the hot England magazine of medication and Lancet. Squibb & Sons got here very with regards to retreating CAPTOPRIL from medical research [2]. in spite of the fact that, after re-evaluation of the information bought from diversified different types of sufferers and acceptable dose-adjustments, the scientific use of CAPTOPRIL grew to become out to be progressive. The prototype, in addition to different individuals of the "PRIL" kinfolk grew to become the place to begin for various uncomplicated and medical learn courses, concentrating on the interactions of ACEI with the kinin, endothelin, and nitric oxide platforms, and the contribution of the receptors for AT I, AT 2, bradykinin Bland B , ETA and ET B to the pharmacological activities 2 of the respective peptides. This examine job resulted in the advance of recent pharmacological brokers, equivalent to the angiotensin receptor antagonists and, extra lately, the impartial endopeptidase inhibitors. within the close to destiny, bradykinin receptor antagonists will also be to be had to modulate ACEI phar­ macological actions.

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E. Plante © 2001 Birkhauser Verlag/Switzerland 29 Crosstalk between ACE inhibitors, B2 kinin receptor and nitric oxide in endothelial cells Paulus Wohlfart, Gabriele Wiemer, Wolfgang Linz and Bemward A. Sch61kens Aventis Pharrna Deutschland GmbH, Disease Groups Research, Building H821, D-65926 FrankfurtlMain, Germany Introduction The endothelium is an important target organ of angiotensin converting enzyme (ACE) inhibitors. Within these monolayered cells establishing the interface between blood and vasculature, a complex signal transduction machinery is the basis for a major role of ACE inhibition in the regulation of vascular homoestasis.

Amer J Cardiol78: 362-364 68 Yoneya K, Okamoto H, Machida M, Onozuka H, Noguchi M, Mikami T, Kawaguchi H, Murakami M, Uede T, Kitabatake A (1995) Angiotensin-converting enzyme gene polymorphism in japanese patients with hypertrophic cardiomyopathy. Amer Heart J 130: 1089-1093 69 Marian A, Yu Q, Workman R, Greve G, Roberts R (1993) Angiotensin-converting enzyme polymorphism in hypertrophic cardiomyopathy and sudden cardiac death. Lancet 342: 1085-1086 70 Tesson F, Dufour C, Moolman J, Carrier L, AI-Mahdawi S, Chojnowska L, Dubourg 0, Soubrier F, Brink P, Komajda M et al (1997) The influence of the angiotensin I converting enzyme genotype in familial hypertrophic cardiomyopathy varies with the disease gene mutation.

Circulation 94: 44-51 8 Brotherton AFA (1986) Induction of prostacyclin biosynthesis is closely associated with guanosine 3',5'-cyclic monophosphate accumulation in cultured human endothelium. J Clin Invest 78: 1253-1260 9 Schini VB, Boulanger C, Regoli D, Vanhoutte PM (1990) Bradykinin stimulates the production of cyclic GMP via activation of B2 kinin receptors in cultured porcine aortic endothelial cells. J Pharmacol Exp Ther 252: 581-585 10 Wohlfart P, Dedio J, Wirth K, SchOikens BA, Wiemer G (1997) Different B) kinin receptorexpression and pharmacology in endothelial cells of different origins and species.

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ACE Inhibitors by John R. Vane (auth.), Pedro D’Orléans-Juste, Gérard E. Plante (eds.)


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