By H. Joachim Deeg M.D., Hans-Georg Klingemann M.D., Ph.D., Gordon L. Phillips M.D., Gary Van Zant Ph.D. (auth.)
This ebook offers an advent to marrow and peripheral blood stem mobilephone transplantation (including wire blood transplants), emphasizing the foundations of this swiftly evolving region. a short old point of view is given and the newest advancements are mentioned. specific realization is given to the reason and symptoms for transplantation, the choice of donors and resource of stem cells, and the separation, enlargement and manipulation of stem cells. crucial points of histocompatibility, preparative regimens utilized in stem phone transplantation, using hematopoietic progress elements and cytokines, the pathophysiology of the graft-versus-host response, and the administration of issues are handled. This publication should still give you the working towards internist, pediatrician, hematologist, and oncologist in addition to different physicians in education or in perform, physicians' assistants, nurses, and scholars with the data essential to comprehend the options of stem mobilephone transplantation and to incorporate transplantation within the therapy making plans quickly after a prognosis has been demonstrated. The textual content also needs to be worthy to the surgeon who resumes the sufferers' care once they go back from the transplant center.
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Additional resources for A Guide to Blood and Marrow Transplantation
Initial results are encouraging. Other Solid Tumors Generally solid tumors do not respond as well even to escalated doses of chemo/radiotherapy as hematological diseases. In adiition most of those patients are heavily pretreated. For the same reason, organ toxicity is more frequently encountered. Patients with neuroblastoma can achieve long-lasting remissions after autografting. Occasional successes have also been reported for patients with glioblastoma prepared with high-dose BeNU for autografting.
Most patients will require some form of treatment largely because of complications related to the enlarged lymph notes. High dose chemo/radiotherapy with stem cell rescue is able to achieve complete responses and possibly cure. Allogeneic transplantation clearly is an option if an HLA-identical sibling is available. Younger patients may even decide to undergo an unrelated transplant. Unlike in CML, it is not clear in patient with CLL how long one can wait before proceeding to transplant without increasing tranplant related complications and tumor resistance.
Although it is still uncertain wether long-term survival with transplantation will be different from what can be achieved with conventional dose salvage therapy, patients undergoing an autograft receive only one round of chemotherapy and generally recover blood counts quickly, whereas conventional dose chemotherapy has to be repeated over and over again. This has led to the argument that autografting, even if providing a higher cure rate in stage IV disease, can improve the quality of life of affected patients and is less cost-intensive than repeated courses of chemotherapy.
A Guide to Blood and Marrow Transplantation by H. Joachim Deeg M.D., Hans-Georg Klingemann M.D., Ph.D., Gordon L. Phillips M.D., Gary Van Zant Ph.D. (auth.)